{"id":3754,"date":"2025-07-03T08:35:40","date_gmt":"2025-07-03T11:35:40","guid":{"rendered":"https:\/\/bionovis.com.br\/medicines\/bevanovis\/"},"modified":"2025-12-08T14:53:04","modified_gmt":"2025-12-08T17:53:04","slug":"bevanovis","status":"publish","type":"page","link":"https:\/\/bionovis.com.br\/en\/medicines\/bevanovis\/","title":{"rendered":"Bevanovis\u00ae"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3754\" class=\"elementor elementor-3754 elementor-2044\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1b60329 e-flex e-con-boxed e-con e-parent\" data-id=\"1b60329\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-b675066 e-con-full e-flex e-con e-child\" data-id=\"b675066\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bd76064 elementor-widget elementor-widget-heading\" data-id=\"bd76064\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-weight:normal\" id=\"docs-internal-guid-80eaac08-7fff-614e-daf6-30ae6bbb7e8d\"><span style=\"font-size: 37.5pt;font-family: Arial, sans-serif;background-color: transparent;font-weight: 700;vertical-align: baseline\">Bevanovis\u00ae <\/span><span style=\"font-size: 19pt;font-family: Arial, sans-serif;background-color: transparent;font-weight: 700;vertical-align: baseline\">(bevacizumab)<\/span><\/span><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1be0e5 elementor-align-left elementor-invisible elementor-widget elementor-widget-breadcrumbs\" data-id=\"d1be0e5\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p id=\"breadcrumbs\"><span><span><a href=\"https:\/\/bionovis.com.br\/en\/\">Home<\/a><\/span><\/span><\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d7d53e e-con-full e-flex e-con e-child\" data-id=\"5d7d53e\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-572e71a elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"572e71a\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Monoclonal antibody that inhibits VEGF and prevents angiogenesis, indicated for the treatment of various types of cancer.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d2b47f e-flex e-con-boxed e-con e-parent\" data-id=\"5d2b47f\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a622b31 e-con-full e-flex e-con e-child\" data-id=\"a622b31\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div class=\"elementor-element elementor-element-0da9968 e-con-full e-flex e-con e-child\" data-id=\"0da9968\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b63d9f elementor-align-left elementor-widget elementor-widget-button\" data-id=\"3b63d9f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bionovis.com.br\/wp-content\/uploads\/2025\/04\/Bula_Bevanovis_Profissional_V1.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-download\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M216 0h80c13.3 0 24 10.7 24 24v168h87.7c17.8 0 26.7 21.5 14.1 34.1L269.7 378.3c-7.5 7.5-19.8 7.5-27.3 0L90.1 226.1c-12.6-12.6-3.7-34.1 14.1-34.1H192V24c0-13.3 10.7-24 24-24zm296 376v112c0 13.3-10.7 24-24 24H24c-13.3 0-24-10.7-24-24V376c0-13.3 10.7-24 24-24h146.7l49 49c20.1 20.1 52.5 20.1 72.6 0l49-49H488c13.3 0 24 10.7 24 24zm-124 88c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20zm64 0c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download the healthcare professional's leaflet<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6c177f elementor-align-left elementor-widget elementor-widget-button\" data-id=\"e6c177f\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/bionovis.com.br\/wp-content\/uploads\/2025\/04\/Bula_Bevanovis_Paciente_V1.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-download\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M216 0h80c13.3 0 24 10.7 24 24v168h87.7c17.8 0 26.7 21.5 14.1 34.1L269.7 378.3c-7.5 7.5-19.8 7.5-27.3 0L90.1 226.1c-12.6-12.6-3.7-34.1 14.1-34.1H192V24c0-13.3 10.7-24 24-24zm296 376v112c0 13.3-10.7 24-24 24H24c-13.3 0-24-10.7-24-24V376c0-13.3 10.7-24 24-24h146.7l49 49c20.1 20.1 52.5 20.1 72.6 0l49-49H488c13.3 0 24 10.7 24 24zm-124 88c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20zm64 0c0-11-9-20-20-20s-20 9-20 20 9 20 20 20 20-9 20-20z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Download patient information leaflet<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff04712 elementor-widget elementor-widget-spacer\" data-id=\"ff04712\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e6da840 e-con-full e-flex e-con e-child\" data-id=\"e6da840\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div class=\"elementor-element elementor-element-5af91c8 e-con-full e-flex e-con e-child\" data-id=\"5af91c8\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61dd23b elementor-widget__width-initial elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"61dd23b\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\"><b>Bevanovis\u00ae<\/b><\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-871ceb7 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"871ceb7\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><font color=\"#595959\">Active Ingredient:  <\/font> Bevacizumab <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bfd0eab e-con-full e-flex e-con e-child\" data-id=\"bfd0eab\" data-element_type=\"container\" id=\"indicado\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-588b78c elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"588b78c\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Indications for Bevacizumab:\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-609ca0d animated-fast elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"609ca0d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Metastatic Colorectal Cancer (mCRC)<\/b> <br \/><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong>, in combination with fluoropyrimidine-based chemotherapy, is indicated for the treatment of patients with metastatic colon or rectal carcinoma.<br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><b>Locally advanced, metastatic, or recurrent non-small cell lung cancer (NSCLC)<\/b> <br \/><br \/><\/p><p><span style=\"font-weight: 400;\">Bevanovis\u00ae, in combination with platinum-based chemotherapy, is indicated as first-line treatment for patients with unresectable, locally advanced, metastatic, or recurrent non-squamous, non-small cell lung cancer (NSCLC).\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong>, in combination with erlotinib, is indicated as first-line treatment for patients with unresectable, advanced, metastatic, or recurrent non-squamous, NSCLC with activating EGFR (epidermal growth factor receptor) mutations.<\/span><\/p><p><b>Metastatic or locally recurrent breast cancer (MBC)<\/b> <br \/><br \/><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong>, in combination with paclitaxel, is indicated as first-line treatment for patients with locally recurrent or metastatic breast cancer who have not received prior chemotherapy for metastatic or locally recurrent disease. Bevanovis\u00ae, in combination with capecitabine, is indicated as first-line treatment for patients with locally recurrent or metastatic breast cancer for whom treatment with other chemotherapy options, including taxanes and anthracyclines, is not considered appropriate. Patients who have received adjuvant therapy regimens containing taxanes and anthracyclines within the last 12 months are not eligible for treatment with Bevanovis\u00ae in combination with capecitabine.<\/span><\/p><p><b>Metastatic and\/or advanced renal cell carcinoma (mRCC)\u00a0<\/b><\/p><p><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong>, in combination with alpha-interferon 2a, is indicated as first-line treatment for patients with advanced and\/or metastatic renal cell carcinoma.<br \/><\/span><\/p><p><b>Epithelial ovarian, fallopian tube, and primary peritoneal cancer <\/b><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Bevanovis\u00ae, in combination with carboplatin and paclitaxel, is indicated as first-line treatment for patients with advanced epithelial ovarian, fallopian tube, and primary peritoneal cancer (International Federation of Gynecology and Obstetrics \u2013 FIGO \u2013 stages III B, III C, and IV). Bevanovis\u00ae, in combination with carboplatin and gemcitabine, is indicated for the treatment of adult patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer with platinum-sensitive first recurrence and no prior therapy with bevacizumab or other VEGF inhibitors or VEGF receptor-targeted agents. Bevanovis\u00ae, in combination with carboplatin and paclitaxel, is indicated for the treatment of adult patients with recurrent, platinum-sensitive epithelial ovarian, fallopian tube, and primary peritoneal cancer.<\/span> <span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Bevanovis\u00ae, in combination with paclitaxel, topotecan, or pegylated liposomal doxorubicin, is indicated for the treatment of patients with recurrent, platinum-resistant epithelial ovarian, fallopian tube, and primary peritoneal cancer who have received no more than two prior chemotherapy regimens and who have not received previous therapy with bevacizumab or other VEGF inhibitors or VEGF receptor-targeted agents. <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><b>Cervical cancer <\/b><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Bevanovis\u00ae, in combination with paclitaxel and cisplatin or, alternatively, paclitaxel and topotecan in patients who cannot receive platinum therapy, is indicated for the treatment of persistent, recurrent, or metastatic cervical cancer.\u00a0\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3ad1417 e-con-full e-flex e-con e-child\" data-id=\"3ad1417\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-20bde80 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"20bde80\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Concentration: <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-82b9dbd animated-fast elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"82b9dbd\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Bevanovis\u00ae solution for dilution for infusion 100 mg<\/b> <span style=\"font-weight: 400;\"><br \/><\/span><b>Active ingredient: bevacizumab<\/b><span style=\"font-weight: 400;\">&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 100 mg (25 mg\/mL). <\/span><span style=\"font-weight: 400;\"><br \/><\/span><b>Excipients:<\/b><span style=\"font-weight: 400;\"> trehalose dihydrate, sodium acetate trihydrate, acetic acid, polysorbate 20, and water for injection. <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><b>Bevanovis\u00ae solution for dilution for infusion 400 mg\u00a0<\/b><\/p><p><b>Active ingredient: bevacizumab<\/b><span style=\"font-weight: 400;\">&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;&#8230;.. 400 mg (25 mg\/mL).\u00a0<\/span><\/p><p><b>Excipients:<\/b><span style=\"font-weight: 400;\"> trehalose dihydrate, sodium acetate trihydrate, acetic acid, polysorbate 20, and water for injection.\u00a0\u00a0<\/span><span style=\"font-weight: 400;\"><br \/><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ddcb91 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3ddcb91\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Presentation:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-978a95f animated-fast elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"978a95f\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong> 100 mg\/4 mL (25 mg\/mL) solution for dilution for infusion in a single-dose vial.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\"><strong>Bevanovis\u00ae<\/strong> 400 mg\/16 mL (25 mg\/mL) solution for dilution for infusion in a single-dose vial.\u00a0<\/span><\/p><p><strong>Intravenous use<\/strong><\/p><p><strong>Adult use.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5d18f99 e-con-full e-flex e-con e-child\" data-id=\"5d18f99\" data-element_type=\"container\" id=\"contraindicacao\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7162bf0 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"7162bf0\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Contraindications:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0831f1 animated-fast elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a0831f1\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Do not use <strong>Bevanovis<\/strong>\u00ae if you are allergic to any component of the product or to other products containing substances similar to bevacizumab. <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\"><br \/><\/span><b>Pregnancy and breastfeeding <\/b><span style=\"font-weight: 400;\"><br \/><\/span><b>This medication should not be used by pregnant women without medical or dental advice. <\/b><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">Post-marketing reports have included cases of fetal abnormalities in women treated with<strong> Bevanovis\u00ae<\/strong> either as monotherapy or in combination with chemotherapeutic agents already known to be embryotoxic (see the package insert section \u201cWhat adverse effects can this medication cause?\u201d). <\/span><span style=\"font-weight: 400;\"><br \/><\/span><span style=\"font-weight: 400;\">If you are a woman of childbearing potential, you must strictly follow your physician\u2019s recommendations to avoid pregnancy during treatment and for at least six months after the last dose of Bevanovis\u00ae.\u00a0<\/span><\/p><p><span style=\"font-weight: 400;\"><br \/><\/span><b>This medication is contraindicated for use by breastfeeding women. <span style=\"font-weight: 400;\"><br \/><\/span><\/b><b><br \/><\/b><span style=\"font-weight: 400;\">It is not known whether <b>bevacizumab<\/b> is excreted in human milk, but this is considered highly likely. Therefore, if you are breastfeeding, you will need to discontinue nursing during treatment and for at least six months after the last dose of Bevanovis\u00ae. \u00a0da \u00faltima dose de <\/span><b>Bevanovis\u00ae<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aff058f e-con-full e-flex e-con e-child\" data-id=\"aff058f\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div class=\"elementor-element elementor-element-80b4c91 e-con-full e-flex e-con e-child\" data-id=\"80b4c91\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-18941e6 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"18941e6\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Especifica\u00e7\u00f5es<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b61bd05 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"b61bd05\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-medicine-syrup\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tType of medication: \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tBiologic antineoplastic; monoclonal antibody.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ae10660 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"ae10660\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-cells\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tClass\/Main Target:\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tAnti-VEGF (angiogenesis inhibitor).\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-12d05e1 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"12d05e1\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-search-area\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tTherapeutic Area (MoA):\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tOncology.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb7d6a8 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"fb7d6a8\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-medical-file\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tPrescription required? \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tSale by prescription only. Restricted to healthcare facilities use. \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-62bc991 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"62bc991\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-refrigerator\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tStorage conditions: \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tStore refrigerated at 2\u00b0C to 8\u00b0C. Do not freeze it. Keep the vial inside its original cartridge to protect it from light. \t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50e2a19 elementor-position-left elementor-mobile-position-left elementor-vertical-align-middle elementor-view-default elementor-widget elementor-widget-icon-box\" data-id=\"50e2a19\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-injection\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tHow to use: \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\tIntravenous (IV). Adult use.\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d69c9dc elementor-position-left elementor-mobile-position-left elementor-view-default elementor-vertical-align-top elementor-widget elementor-widget-icon-box\" data-id=\"d69c9dc\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-file-alt\" viewBox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M288 248v28c0 6.6-5.4 12-12 12H108c-6.6 0-12-5.4-12-12v-28c0-6.6 5.4-12 12-12h168c6.6 0 12 5.4 12 12zm-12 72H108c-6.6 0-12 5.4-12 12v28c0 6.6 5.4 12 12 12h168c6.6 0 12-5.4 12-12v-28c0-6.6-5.4-12-12-12zm108-188.1V464c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V48C0 21.5 21.5 0 48 0h204.1C264.8 0 277 5.1 286 14.1L369.9 98c9 8.9 14.1 21.2 14.1 33.9zm-128-80V128h76.1L256 51.9zM336 464V176H232c-13.3 0-24-10.7-24-24V48H48v416h288z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tRegistration No.: 1.4531.0002.001-3 \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t25 MG\/ML IV INFUSION DILUTED SOLUTION, CLEAR GLASS VIAL, 4 ML\n\n\n1.4531.0002.002-1 \n25 MG\/ML IV INFUSION DILUTED SOLUTION, CLEAR GLASS VIAL, 16 ML.\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c3e09a elementor-position-left elementor-mobile-position-left elementor-view-default elementor-vertical-align-top elementor-widget elementor-widget-icon-box\" data-id=\"1c3e09a\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"huge huge-google-doc\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t1.4531.0002.002-1 \n25 MG\/ML IV INFUSION DILUTED SOLUTION, CLEAR GLASS VIAL, 16 ML.\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9be15a3 e-con-full e-flex e-con e-child\" data-id=\"9be15a3\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-83bb499 elementor-widget elementor-widget-spacer\" data-id=\"83bb499\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0c5d1d elementor-alert-info elementor-widget elementor-widget-alert\" data-id=\"f0c5d1d\" data-element_type=\"widget\" data-widget_type=\"alert.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-alert\" role=\"alert\">\n\n\t\t\t\t\t\t<span class=\"elementor-alert-title\">SOURCE: Bevanovis\u00ae Package Insert<\/span>\n\t\t\t\n\t\t\t\t\t\t<span class=\"elementor-alert-description\">The responsible use of medications is essential for treatment safety and efficacy. Self-medication may mask symptoms, cause adverse effects, and compromise health. Prescription medicines must be used only under the guidance of a qualified healthcare professional.\n<\/span>\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35468e8 elementor-widget elementor-widget-spacer\" data-id=\"35468e8\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4976291 e-con-full e-flex e-con e-child\" data-id=\"4976291\" data-element_type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-36e9009 elementor-widget__width-initial animated-fast elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"36e9009\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Frequently Asked Questions:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5dd6e84 elementor-icon-list--layout-traditional elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"5dd6e84\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul class=\"elementor-icon-list-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#indicado\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"hm hm-arrow-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">What is bevacizumab used for? <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#indicado\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"hm hm-arrow-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">When is bevacizumab indicated?<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#contraindicacao\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"hm hm-arrow-right\"><\/i>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">What are the bevacizumab contraindications? <\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Bevanovis\u00ae (bevacizumab) Monoclonal antibody that inhibits VEGF and prevents angiogenesis, indicated for the treatment of various types of cancer. Download the healthcare professional&#8217;s leaflet Download patient information leaflet Bevanovis\u00ae Active Ingredient: Bevacizumab Indications for Bevacizumab: Metastatic Colorectal Cancer (mCRC) Bevanovis\u00ae, in combination with fluoropyrimidine-based chemotherapy, is indicated for the treatment of patients with metastatic colon [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2944,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-3754","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.4 (Yoast SEO v25.4) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Bevanovis\u00ae - Bionovis<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bionovis.com.br\/en\/medicines\/bevanovis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bevanovis\u00ae\" \/>\n<meta property=\"og:description\" content=\"Bevanovis\u00ae (bevacizumab) Monoclonal antibody that inhibits VEGF and prevents angiogenesis, indicated for the treatment of various types of cancer. 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